In this lecture, anthropologist and Bosch Public Policy Fellow Jason Pine looks at small-scale methamphetamine manufacture in rural Missouri to ask how meth cooking and consumption are used to enhance or “get more life.” He explains the fieldwork he conducted among meth cooks, narcotic agents, judges, parole officers, physicians, pastors, and a St. Louis pharmaceutical laboratory. He also traces the contours of alternative biotechno-ecologies, where “rogue” consumers unmake common household products to create elixirs for fatigue, deflation, and dispossession. Like Pine’s other research projects, the focus of this lecture is on people’s everyday pursuits of personal sovereignty in alternative economies. In his study of small-scale DIY methlabs, he explores how people engage in the alchemical work of self-production as they make do with the toxic inheritance of late-industrial landscapes.